Pre-clinical research
Angiogenesis
| Easy Imaging | Plasma Labelling | Back to Applications |
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Cancer Research Travel into vessels, easily.
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Easy Imaging
Traditional intravital microscopic imaging requires a tedious preparation of the animal. With Cellvizio® LAB, minimally invasive dynamic imaging is as simple as placing the probe on the area of interest.
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A small two-mm incision of the skin is enough for imaging with Cellvizio Lab and its tiny microprobes... ► more |
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Vessel Detection™ Tool
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Get better resolution inside a larger Field of View Follow vessel course within its environment... |
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Examples of imaging protocols
Plasma labelling
Inject a plasma-labeling dye IV, then put the ProFlex in contact with the tissue to reveal the entire circulatory system.
This protocol is very commonly used, its description can be found in various publications.
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Imaging angiogenesis on a PC3 prostate subcutaneous tumor model after injection of 250 kDa FITC-Dextran.
Courtesy of Anne-Carole Duconseille, Charles A. Cuenod and Olivier Clément, Descartes Image, Small Animal Imaging Facility, Université Paris V, Paris, France
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[video:nid:442] |
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Capillaries of a mouse subcutaneous prostate tumor stained with FITC-Albumin.
Courtesy of Nathalie Faye, Laure Fournier, Charles A. Cuenod and Olivier Clément, Descartes Image, Small Animal Imaging Facility, Université Paris V, Paris, France |
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Longitudinal study of Angiogenesis over time (PC3 prostate subcutaneous tumor, FITC-Dextran injection)
Courtesy of Anne-Carole Duconseille, Charles A. Cuenod and Olivier Clément, Descartes Image, Small Animal Imaging Facility, Université Paris V, Paris, France |
[video:nid:707] |
Visualization of cells or platelets
Blood cells labelling can give critical information about the cell-wall interactions.
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Leukocytes can be imaged by intravenous injection of Rhodamine 6G as illustrated by the movie on the right.
Courtesy of Elisabeth Laemmel and Eric Vicaut, LEM, Paris, France.
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